Reengineering orthogonally selective riboswitches.

Stability and hyperstability of orthogonally ring $*$-$n$-derivations and orthogonally ring $*$-$n$-homomorphisms on $C^*$-algebras

In this paper, we investigate the generalized Hyers-Ulam-Rassias and the Isac and Rassias-type stability of the conditional of orthogonally ring $*$-$n$-derivation and orthogonally ring $*$-$n$-homomorphism on $C^*$-algebras. As a consequence of this, we prove the hyperstability of orthogonally ring $*$-$n$-derivation and orthogonally ring $*$-$n$-homomorphism on $C^*$-algebras.

Novel Riboswitch Ligand Analogs as Selective Inhibitors of Guanine-Related Metabolic Pathways

Riboswitches are regulatory elements modulating gene expression in response to specific metabolite binding. It has been recently reported that riboswitch agonists may exhibit antimicrobial properties by binding to the riboswitch domain. Guanine riboswitches are involved in the regulation of transport and biosynthesis of purine metabolites, which are critical for the nucleotides cellular pool. U...

On the Stability of the Orthogonally Quartic Functional Equation

Selective binding of 2'-F-c-di-GMP to Ct-E88 and Cb-E43, new class I riboswitches from Clostridium tetani and Clostridium botulinum respectively.

C-di-GMP is a second messenger in bacteria and partly regulates bacterial physiology by binding to class I and II riboswitches. Four class I c-di-GMP riboswitch aptamer candidates, Ct-E88, Cb-17B, Cb-E43 and Cd-630 RNAs, selected from a GEMM RNA sequence motif in the Rfam database, were expressed and experimentally verified to bind to c-di-GMP. The two newly characterized c-di-GMP riboswitches,...

Structural analysis of a class III preQ1 riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics.

PreQ1-III riboswitches are newly identified RNA elements that control bacterial genes in response to preQ1 (7-aminomethyl-7-deazaguanine), a precursor to the essential hypermodified tRNA base queuosine. Although numerous riboswitches fold as H-type or HLout-type pseudoknots that integrate ligand-binding and regulatory sequences within a single folded domain, the preQ1-III riboswitch aptamer for...